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Life Sciences & Biotech | Medicine
Oxidated Fe, Cu and Zn in breast tumor tissue - image

Oxidated Fe, Cu and Zn in breast tumor tissue

Excessive accumulation of copper, zinc and iron in breast cancer compared to normal breast tissues has been reported in a number of studies. The observation of such differences in bulk samples has in the last few years been followed up by small-beam imaging that allows metal levels to be mapped across a specimen revealing preferential sites of accumulation. read more

 
Life Sciences & Biotech | Medicine
Ptychographic X-ray computed tomography at the nanoscale - image

Ptychographic X-ray computed tomography at the nanoscale

A novel nano-tomography method developed by a team of researchers from the Technische Universität München TUM, the Paul Scherrer Institute PSI and the ETH Zurich opens the door to computed tomography examinations of minute structures at nanometer resolutions.  read more

 
Life Sciences & Biotech | Medicine
Local analysis of levels, speciation and chemical environments of zinc and copper in brain gliomas - image

Local analysis of levels, speciation and chemical environments of zinc and copper in brain gliomas

X-ray absorption near-edge structure spectroscopy is used for human neoplastic tissues in order to investigate distributions and chemical states of iron. The specimens used in this study were obtained intraoperatively from brain gliomas of different types and various grades of malignancy and from a control subject. An integrated experimental and analytical approach toward topographic and quantitative analysis in thin freeze-dried cryo-sections is presented. read more

 
Life Sciences & Biotech | Molecular and cellular biology
Looking by infrared microscopy inside human Cells  - image

Looking by infrared microscopy inside human Cells

The « AFMIR » infrared imaging technique, invented at CLIO, allows to map objects such as living cells with a high spatial resolution (< 100nm). In this example the cell located by AFM topography (a) is imaged in the infrared band characteristic of the nucleus (b) and of the compound whose localisation is searched, showing that it is located at the nucleus as expected. This technique avoids the use of any tag perturbing the biological process. read more

 
Life Sciences & Biotech | Molecular and cellular biology
FTIR characterization of vascular endothelial cells - image

FTIR characterization of vascular endothelial cells

Fourier-transform infrared (FTIR) imaging has been used to investigate brain tumor angiogenesis using a mice solid tumor model. FTIR images of 20-μm-thick tissue sections were used for chemical histology of healthy and tumor areas. read more

 
Life Sciences & Biotech | Molecular and cellular biology
X-ray cryo-tomography of vaccinia virus infected cells - image

X-ray cryo-tomography of vaccinia virus infected cells

X-ray cryo-tomography (XCT) at the HZB full-filed X-ray microscope was applied to obtain, for the first time, a complete cartographic description of the maturation process of the vaccinia virus within whole unperturbed cells. read more

 
Life Sciences & Biotech | Molecular and cellular biology
Copper scorpionate as potential anticancer drug - image

Copper scorpionate as potential anticancer drug

The knowledge of the local atomic environment of copper in inorganic complexes containing scorpionate-based ligands is essential to study the relationship between cytotoxic activity and structure of the complexes. X-ray Absorption Spectroscopy (XAS) experiments at the XAFS beamline provide the relevant structural information. The joint XAS and biological data evaluation allows to design new ligands useful for the synthesis of novel copper derivatives to be further evaluated as alternative anticancer drugs. read more

 
Life Sciences & Biotech | Molecular and cellular biology
In vivo skin leptin modulation after 14 MeV neutron irradiation: a molecular and FT-IR spectroscopic study - image

In vivo skin leptin modulation after 14 MeV neutron irradiation: a molecular and FT-IR spectroscopic study

Monitoring of the resultant lipid depletion (cross-validated by functional genomic analysis) as a marker of the 14 MeV neutron irradiation of skin of mice using high-resolution FT-IR (Fourier transform infrared) imaging spectroscopy.  read more

 
Life Sciences & Biotech | Molecular and cellular biology
Protein structure revealed that gives clues to fight malaria - image

Protein structure revealed that gives clues to fight malaria

For the first time, researchers have been able to determine the three-dimensional structure of an important membrane protein that regulates the ion balance of cells. The findings open up new possibilities to fight diseases such as malaria and sleeping sickness and have recently been published in the journal Science. read more

 
Life Sciences & Biotech | Molecular and cellular biology

Small angle X-ray studies of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) enriched membranes

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel with complex regulation. It is predominantly expressed in the apical membrane of epithelia, where it provides a pathway for anion movement and regulates fluid flow.  read more

 
 

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